Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 6/20 | 0.45 |
| ▸ | PLK4 | O00444 | 5/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | FLT4 | P35916 | 4/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1662894 | 0.78 | PLK4 (0.38) | PAK4PLK4HTR2AHTR2CAR | |
| SCHEMBL1662982 | 0.69 | JAK3 (0.42) | PAK4PLK4HTR2AHTR2CEGFR | |
| SCHEMBL1662557 | 0.68 | JAK3 (0.41) | PAK4PLK4HTR2AHTR2CFLT4 | |
| SCHEMBL1665152 | 0.66 | JAK3 (0.46) | — | |
| SCHEMBL15547643 | 0.66 | JAK2 (0.55) | FLT4KDR | |
| SCHEMBL1662898 | 0.66 | JAK3 (0.39) | HTR2AHTR2CFLT4KDR | |
| SCHEMBL1662410 | 0.65 | STAT6 (0.43) | FLT4KDRTP53LMNA | |
| SCHEMBL30332046 | 0.65 | IDO1 (0.40) | ARALDH1A1 | |
| Hydrochloric Acid SCHEMBL29271435 | 0.64 | IDO1 (0.42) | ARALDH1A1 | |
| SCHEMBL15547186 | 0.62 | FLT4 (0.41) | FLT4KDRALDH1A1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491039-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | Cellzome Limited (GB) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011048082-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2011-04-28 | — | — | WO | disclosed |