Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 7/20 | 0.42 |
| ▸ | BTK | Q06187 | 4/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | PLK4 | O00444 | 2/20 | 0.39 |
| ▸ | PAK4 | O96013 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 4/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1662557 | 0.91 | JAK3 (0.41) | JAK3BTKALKHTR2CJAK2 | |
| SCHEMBL1663028 | 0.84 | JAK3 (0.47) | JAK3BTKALKHTR2CJAK2 | |
| SCHEMBL1665152 | 0.81 | JAK3 (0.46) | JAK3BTKALKJAK2JAK1 | |
| SCHEMBL1662830 | 0.81 | JAK3 (0.41) | JAK3BTKALKHTR2CJAK2 | |
| SCHEMBL1665417 | 0.78 | FLT4 (0.42) | JAK3BTKALKJAK2JAK1 | |
| SCHEMBL1662898 | 0.77 | JAK3 (0.39) | JAK3BTKALKHTR2CJAK2 | |
| SCHEMBL1662711 | 0.77 | JAK3 (0.42) | JAK3BTKJAK2JAK1PLK4 | |
| SCHEMBL1663011 | 0.75 | TTK (0.45) | JAK3BTKALKHTR2CJAK2 | |
| SCHEMBL1665191 | 0.74 | JAK1 (0.43) | JAK3BTKJAK2JAK1TYK2 | |
| SCHEMBL1662793 | 0.72 | PLK4 (0.46) | JAK3BTKJAK2JAK1PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491039-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | Cellzome Limited (GB) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011048082-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2011-04-28 | — | — | WO | disclosed |