Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CALCRL | Q16602 | 4/20 | 0.38 |
| ▸ | SDCBP | O00560 | 1/20 | 0.38 |
| ▸ | SDC2 | P34741 | 1/20 | 0.38 |
| ▸ | RAMP1 | O60894 | 3/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | PER2 | O15055 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL311838 | 1.00 | MAPK1 (0.45) | MAPK1BRD4CREBBPALOX15CALCRL | |
| SCHEMBL1055688 | 0.78 | TOP2A (0.34) | — | |
| SCHEMBL828518 | 0.75 | BRD4 (0.61) | MAPK1BRD4CREBBPALOX15 | |
| SCHEMBL3425970 | 0.70 | MAPK1 (0.64) | MAPK1BRD4CREBBP | |
| SCHEMBL12848410 | 0.70 | BRD4 (0.54) | MAPK1BRD4CREBBPALOX15PER2 | |
| SCHEMBL23348860 | 0.68 | SDCBP (0.62) | SDCBPSDC2LMNATP53 | |
| SCHEMBL21616210 | 0.68 | SDCBP (0.62) | SDCBPSDC2LMNATP53 | |
| SCHEMBL22716676 | 0.68 | MAPK1 (0.55) | MAPK1BRD4CREBBPALOX15CALCRL | |
| SCHEMBL30955020 | 0.68 | SDCBP (0.62) | SDCBPSDC2LMNATP53 | |
| SCHEMBL22152235 | 0.67 | MAPK1 (0.35) | MAPK1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2308844-A2 | Caspase inhibitors and uses thereof | Vertex Pharmceuticals Incorporated (US) | 2011-04-13 | — | — | EP | disclosed |