Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 18/20 | 1.00 |
| ▸ | RPS6KB1 | P23443 | 18/20 | 1.00 |
| ▸ | RPS6KA1 | Q15418 | 6/20 | 1.00 |
| ▸ | PRKCB | P05771 | 4/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1662473 | 1.00 | AKT1 (1.00) | AKT1RPS6KB1RPS6KA1PRKCB | |
| SCHEMBL9894202 | 0.98 | RPS6KB1 (0.97) | AKT1RPS6KB1RPS6KA1PRKCB | |
| SCHEMBL9894200 | 0.98 | RPS6KB1 (0.97) | AKT1RPS6KB1RPS6KA1PRKCB | |
| SCHEMBL9927845 | 0.94 | AKT1 (0.89) | AKT1RPS6KB1RPS6KA1PRKCB | |
| SCHEMBL16457530 | 0.94 | AKT1 (0.89) | AKT1RPS6KB1RPS6KA1PRKCB | |
| SCHEMBL9894876 | 0.94 | AKT1 (0.88) | AKT1RPS6KB1RPS6KA1PRKCB | |
| SCHEMBL16457073 | 0.94 | AKT1 (0.88) | AKT1RPS6KB1RPS6KA1PRKCB | |
| SCHEMBL9894875 | 0.94 | AKT1 (0.88) | AKT1RPS6KB1RPS6KA1PRKCB | |
| SCHEMBL9927844 | 0.94 | AKT1 (0.88) | AKT1RPS6KB1RPS6KA1PRKCB | |
| SCHEMBL9894299 | 0.93 | AKT1 (0.87) | AKT1RPS6KB1RPS6KA1PRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491032-B1 | AKT INHIBITORS | LILLY CO ELI (US) | 2014-04-16 | — | — | EP | claimed |
| US-20200268897-A1 | Phosphatase Binding Compounds and Methods of Using Same | YALE UNIVERSITY | 2020-08-27 | — | — | US | disclosed |
| EP-2491032-B1 | AKT INHIBITORS | LILLY CO ELI (US) | 2014-04-16 | — | — | EP | disclosed |
| EP-2491032-B1 | AKT INHIBITORS | LILLY CO ELI (US) | 2014-04-16 | — | — | EP | disclosed |
| US-8436002-B2 | AKT inhibitors | ELI LILLY AND COMPANY (US) | 2013-05-07 | — | — | US | disclosed |
| US-8436002-B2 | AKT inhibitors | ELI LILLY AND COMPANY (US) | 2013-05-07 | — | — | US | disclosed |
| US-8436002-B2 | AKT inhibitors | ELI LILLY AND COMPANY (US) | 2013-05-07 | — | — | US | disclosed |
| EP-2491032-A1 | AKT INHIBITORS | Eli Lilly and Company (US) | 2012-08-29 | — | — | EP | disclosed |
| US-20120149684-A1 | AKT INHIBITORS | ELI LILLY AND COMPANY (US) | 2012-06-14 | — | — | US | disclosed |
| US-20120149684-A1 | AKT INHIBITORS | ELI LILLY AND COMPANY (US) | 2012-06-14 | — | — | US | disclosed |
| US-20120149684-A1 | AKT INHIBITORS | ELI LILLY AND COMPANY (US) | 2012-06-14 | — | — | US | disclosed |
| WO-2011050016-A1 | AKT INHIBITORS | ELI LILLY AND COMPANY (US) | 2011-04-28 | — | — | WO | disclosed |
| WO-2011050016-A1 | AKT INHIBITORS | ELI LILLY AND COMPANY (US) | 2011-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149684-A1 | AKT INHIBITORS | AKT2, PIK3CA, AKT3 | AKT1 4/4885RPS6KB1 41/4885RPS6KA1 47/4885 |
| US-20200268897-A1 | Phosphatase Binding Compounds and Methods of Using Same | PPP5C, PPP4C, DUSP26 | AKT1 516/4885RPS6KB1 780/4885RPS6KA1 888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.