PPP4C

Serine/threonine-protein phosphatase 4 catalytic subunit · P60510 · PPP4C on Sugi Atlas →

69 patent compounds predicted against PPP4C, 52 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Fostriecin (SCHEMBL62527)	1.00	1/20
Fostriecin (SCHEMBL469219)	1.00	1/20
Fostriecin (SCHEMBL10030539)	1.00	1/20
Fostriecin (SCHEMBL10738892)	1.00	1/20
Fostriecin (SCHEMBL10738899)	1.00	1/20
Fostriecin (SCHEMBL5052)	0.98	1/20
Fostriecin (SCHEMBL21408783)	0.86	1/20
Fostriecin (SCHEMBL29370092)	0.86	1/20
Fostriecin (SCHEMBL31052709)	0.86	1/20
SCHEMBL442237	0.86	1/20
SCHEMBL444441	0.86	1/20
SCHEMBL10733047	0.85	1/20
SCHEMBL469218	0.84	1/20
SCHEMBL442231	0.82	1/20
Alfadex (SCHEMBL10428641)	0.80	1/20
SCHEMBL442234	0.79	1/20
SCHEMBL444877	0.79	1/20
SCHEMBL442224	0.77	1/20
SCHEMBL12954806	0.77	1/20
SCHEMBL17897625	0.76	1/20

Clinical trials — most relevant to PPP4C by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Rectal Tacrolimus in the Treatment of Resistant Ulcerative Proctitis	PHASE4	COMPLETED
Lithium for Prevention of Cognitive Declining in Mood Illnesses	PHASE4	NOT_YET_RECRUITING
Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients	PHASE3	ACTIVE_NOT_RECRUITING
Evaluate Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients	PHASE3	COMPLETED
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients	PHASE1/PHASE2	WITHDRAWN
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
Study Evaluating Toxicity & Efficacy of Lenalidomide(Revlimid®)in Chemotherapy-Naïve AIPC Patients	PHASE2	COMPLETED
Rapamycin Treatment for Activated Phosphoinositide 3-Kinase δ Syndrome	PHASE1/PHASE2	COMPLETED
Study of Decitabine in Combination With Sequential Rapamycin or Ribavirin in High Risk AML Patients	PHASE1/PHASE2	COMPLETED
A Pilot Study Evaluating the Use of mTor Inhibitor Sirolimus in Children and Young Adults With Desmoid-Type Fibromatosis	PHASE1/PHASE2	COMPLETED
Evaluating MED2005 & Nitrostat Bioavailability	PHASE1	COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Nilotinib in Huntington's Disease	PHASE1	UNKNOWN
Bioequivalence Study of Tacrolimus in Healthy Volunteers	PHASE1	COMPLETED
Phase I Dose Finding and Proof-of-concept Study of Panobinostat With Standard Dose Cytarabine and Daunorubicin for Untreated Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome	PHASE1	COMPLETED
Phase I Study of SC-43 Oral Solution in Subjects With Refractory Solid Tumors	PHASE1	WITHDRAWN
Phase 0/1 Biomarker and Pharmacodynamic Study of Roflumilast in Patients With Advanced B-Cell Hematologic Malignancies (CTRC# 13-0013)	EARLY_PHASE1	COMPLETED
Quantification of GADD34 Expression in RA	nan	COMPLETED
Lymphoid Tyrosine Phosphatase Gene Polymorphisms in Inflammatory Bowel Disease	nan	UNKNOWN
Immune Signature of Palmoplantar Pustulosis	nan	COMPLETED
Effect of Esterogen Receptor Modulator on Gene in Bipolar Diseas	nan	NOT_YET_RECRUITING
NGS in Gallbladder Cancer and Response to Treatment	nan	RECRUITING
Duality of Lipids: the Athlete's Paradox	nan	COMPLETED
Transcutaneous Electrical Diaphragmatic Stimulation in Critically Ill Elderly Patients	nan	UNKNOWN
IVF Outcome in Polycystic Ovary Syndrome Patients	nan	UNKNOWN
Studying The Role of Key Epigenetic Mediators in Breast Cancer Patients	nan	RECRUITING
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Monitoring of Breathing Effort Through Pressure Time Product Measurement Using Airway Occlusion Pressure	nan	UNKNOWN
p-AKT Expression on Clinical Outcomes in Malignant Lymphoma	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PPP4C binder may also engage these)

Protein	Name	Similarity
A6H772	—	1.000	A6H772 →
P11084	—	1.000	P11084 →
P97470	—	1.000	P97470 →
Q5R6K8	—	1.000	Q5R6K8 →
Q5BJ92	—	1.000	Q5BJ92 →
P48528	—	1.000	P48528 →
A9JRC7	—	1.000	A9JRC7 →
Q6P861	—	1.000	Q6P861 →
A8WGP3	—	1.000	A8WGP3 →
Q9XZE5	—	1.000	Q9XZE5 →
P48463	—	1.000	P48463 →
A0C1E4	—	1.000	A0C1E4 →
P23696	—	1.000	P23696 →
P63330	—	1.000	P63330 →
Q6IP91	—	1.000	Q6IP91 →
PPP2CA	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	1.000	landscape →
P23778	—	1.000	P23778 →
O76932	—	1.000	O76932 →
A2XN40	—	1.000	A2XN40 →
Q07100	—	1.000	Q07100 →
Q9Y0B7	—	1.000	Q9Y0B7 →
P36614	—	1.000	P36614 →
A0CCD2	—	1.000	A0CCD2 →
Q9XGH7	—	1.000	Q9XGH7 →
Q10BT5	—	1.000	Q10BT5 →
Q27884	—	0.999	Q27884 →
Q0E2S4	—	0.999	Q0E2S4 →
P0C5D7	—	0.999	P0C5D7 →
Q9XW79	—	0.999	Q9XW79 →
Q0DBD3	—	0.999	Q0DBD3 →