Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | PLAU | P00749 | 2/20 | 0.38 |
| ▸ | ELANE | P08246 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23229770 | 0.81 | RXFP1 (0.51) | RXFP1SMN1; SMN2LMNAMAPK1F2 | |
| SCHEMBL574383 | 0.77 | RXFP1 (0.49) | RXFP1SMN1; SMN2LMNAMAPK1F2 | |
| SCHEMBL19010734 | 0.77 | RXFP1 (0.53) | RXFP1SMN1; SMN2LMNAMAPK1F2 | |
| SCHEMBL30962934 | 0.75 | SMN1; SMN2 (0.44) | RXFP1SMN1; SMN2LMNAMAPK1F2 | |
| SCHEMBL23675079 | 0.75 | SMN1; SMN2 (0.46) | RXFP1SMN1; SMN2LMNAMAPK1F2 | |
| SCHEMBL19010737 | 0.74 | RXFP1 (0.56) | RXFP1SMN1; SMN2LMNAMAPK1F2 | |
| SCHEMBL16975455 | 0.74 | SMN1; SMN2 (0.45) | RXFP1SMN1; SMN2LMNAMAPK1F2 | |
| SCHEMBL1662833 | 0.73 | — | — | |
| SCHEMBL31085494 | 0.72 | ACHE (0.48) | RXFP1SMN1; SMN2LMNAMAPK1F2 | |
| SCHEMBL25438635 | 0.71 | RXFP1 (0.44) | RXFP1SMN1; SMN2LMNAMAPK1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491039-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | Cellzome Limited (GB) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011048082-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2011-04-28 | — | — | WO | disclosed |