Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.55 |
| ▸ | EIF4E | P06730 | 2/20 | 0.49 |
| ▸ | FYN | P06241 | 5/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.44 |
| ▸ | MTOR | P42345 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | TYK2 | P29597 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18012900 | 0.86 | MKNK1 (0.58) | MKNK1MKNK2LRRK2 | |
| SCHEMBL17998743 | 0.85 | MTOR (0.48) | MKNK1MKNK2EIF4ELRRK2PIK3CA | |
| Formic Acid SCHEMBL16620929 | 0.82 | MTOR (0.46) | MKNK1MKNK2EIF4ELRRK2PIK3CA | |
| Formic Acid SCHEMBL29756329 | 0.82 | MTOR (0.46) | MKNK1MKNK2EIF4ELRRK2PIK3CA | |
| SCHEMBL16620529 | 0.82 | MKNK1 (0.52) | MKNK1MKNK2EIF4ELRRK2PIK3CA | |
| SCHEMBL15288465 | 0.79 | MKNK1 (0.75) | MKNK1MKNK2EIF4EFYNCYP3A4 | |
| SCHEMBL21644093 | 0.76 | FYN (0.49) | MKNK1MKNK2FYN | |
| SCHEMBL16625807 | 0.76 | MKNK1 (0.46) | MKNK1MKNK2EIF4ELRRK2PIK3CA | |
| SCHEMBL18012895 | 0.75 | MKNK1 (0.55) | MKNK1MKNK2FYNLRRK2MTOR | |
| SCHEMBL18012892 | 0.75 | MKNK1 (0.55) | MKNK1MKNK2FYNLRRK2MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015050505-A1 | BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2015-04-09 | — | — | WO | disclosed |