Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 6/20 | 0.62 |
| ▸ | JAK2 | O60674 | 3/20 | 0.53 |
| ▸ | CDK9 | P50750 | 3/20 | 0.53 |
| ▸ | MARK3 | P27448 | 3/20 | 0.53 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.53 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.53 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.53 |
| ▸ | SLK | Q9H2G2 | 3/20 | 0.53 |
| ▸ | TYK2 | P29597 | 2/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.53 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | STK10 | O94804 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | PRKCB | P05771 | 1/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.53 |
| ▸ | TOP2A | P11388 | 1/20 | 0.53 |
| ▸ | PRKCA | P17252 | 1/20 | 0.53 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1050911 | 0.81 | TGFBR1 (0.60) | CDK9ROCK2ROCK1TAOK1DYRK1A | |
| SCHEMBL8942167 | 0.80 | DYRK1A (0.59) | CDK9ROCK1TAOK1DYRK1APDPK1 | |
| SCHEMBL21014989 | 0.80 | CYP3A4 (0.49) | JAK3JAK2CDK9MARK3PRKCD | |
| SCHEMBL1666229 | 0.79 | CDC7 (0.63) | JAK3JAK2CDK9MARK3PRKCD | |
| SCHEMBL14886136 | 0.79 | JAK3 (0.53) | JAK3JAK2CDK9MARK3PRKCD | |
| SCHEMBL2633664 | 0.79 | JAK2 (0.52) | JAK3JAK2CDK9CYP1A2CYP3A4 | |
| SCHEMBL14555147 | 0.78 | JAK3 (0.60) | JAK3JAK2CDK9MARK3PRKCD | |
| SCHEMBL16626024 | 0.78 | JAK3 (0.65) | JAK3JAK2CDK9MARK3PRKCD | |
| SCHEMBL14883444 | 0.77 | JAK3 (0.78) | JAK3JAK2CDK9MARK3PRKCD | |
| SCHEMBL19832092 | 0.77 | JAK3 (0.64) | JAK3JAK2CDK9MARK3PRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3141548-B9 | PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES | VERTEX PHARMA (US) | 2020-08-12 | — | — | EP | disclosed |
| US-9090614-B2 | Processes and intermediates for producing azaindoles | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-07-28 | — | — | US | disclosed |
| US-20150099884-A1 | PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES | VERTEX PHARMACEUTICALS INCORPORATED | 2015-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150099884-A1 | PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES | JAK2, JAK3, JAK1 | JAK3 2/4885JAK2 1/4885CDK9 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.