Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | LPO | P22079 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 3/20 | 0.38 |
| ▸ | CDK8 | P49336 | 3/20 | 0.38 |
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | NMT1 | P30419 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10194263 | 0.83 | KDM4E (0.51) | HDAC4BRD4KDM5BLPOKDM4E | |
| SCHEMBL9281044 | 0.80 | HDAC4 (0.54) | HDAC4BRD4KDM4ENPC1RAB9A | |
| SCHEMBL77337 | 0.80 | HDAC4 (0.47) | HDAC4BRD4KDM5BLPOKDM4E | |
| SCHEMBL10558737 | 0.80 | NR1H2 (0.45) | HDAC4BRD4KDM5BLPOKDM4E | |
| SCHEMBL9451409 | 0.80 | HDAC4 (0.47) | HDAC4BRD4KDM5BLPOKDM4E | |
| SCHEMBL3462133 | 0.80 | HDAC4 (0.46) | HDAC4BRD4KDM5BLPOKDM4E | |
| SCHEMBL2326291 | 0.80 | IDO1 (0.47) | HDAC4BRD4KDM5BLPOKDM4E | |
| SCHEMBL786747 | 0.79 | HDAC4 (0.52) | HDAC4BRD4LPOKDM4ENPC1 | |
| SCHEMBL14960619 | 0.79 | MAPK9 (0.44) | HDAC4BRD4KDM5BLPOKDM4E | |
| SCHEMBL16984616 | 0.78 | USP2 (0.45) | HDAC4BRD4LPOKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9597310-B2 | Indanyloxydihydrobenzofuranylacetic acids | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-03-21 | — | — | US | disclosed |
| WO-2015049574-A1 | 4-AZAINDOLE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-09 | — | — | WO | disclosed |