Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.31 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.31 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29117284 | 0.85 | MAPK1 (0.37) | KDM4EMAPK1L3MBTL1MEN1MAPT | |
| SCHEMBL31435809 | 0.81 | KCNA3 (0.33) | KCNA3MEN1KMT2A | |
| SCHEMBL3877084 | 0.81 | CYP2C19 (0.47) | KDM4EMAPK1PTGS1ITGB1ITGA4 | |
| SCHEMBL4518 | 0.80 | MAPK1 (0.52) | KDM4EMAPK1L3MBTL1MEN1MAPT | |
| SCHEMBL19767 | 0.79 | CPB2 (0.35) | KCNA3MEN1KMT2A | |
| SCHEMBL28278251 | 0.79 | CYP2C19 (0.50) | KDM4EMAPK1PTGS1ITGB1ITGA4 | |
| SCHEMBL17049040 | 0.76 | CPB2 (0.39) | KDM4EMEN1KMT2A | |
| SCHEMBL30342289 | 0.76 | KMT2A (0.33) | KDM4EMAPK1L3MBTL1MEN1MAPT | |
| SCHEMBL28683771 | 0.76 | CYP4F2 (0.38) | KDM4EMAPK1L3MBTL1MEN1MAPT | |
| SCHEMBL25174478 | 0.75 | MAPK1 (0.41) | KDM4EMAPK1L3MBTL1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2688881-B1 | NEW AZASPIRODECANONE COMPOUNDS AS HSL INHIBITORS | HOFFMANN LA ROCHE (CH) | 2016-02-10 | — | — | EP | disclosed |
| EP-2488493-B1 | SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS HSL INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES | HOFFMANN LA ROCHE (CH) | 2015-04-15 | — | — | EP | disclosed |