SCHEMBL16628713

SCHEMBL16628713

Nc1nc(C(=O)N2Cc3ccc(O)cc3C2)c2ccccc2n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 12/20 1.00
HSP90AB1 P08238 4/20 1.00
ADORA3 P0DMS8 3/20 0.45
MAOB P27338 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.43
HPGD P15428 1/20 0.40
DCPS Q96C86 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3093806 0.89 HSP90AA1 (1.00) HSP90AA1HSP90AB1ADORA3SMN1; SMN2HPGD
SCHEMBL16628686 0.88 HSP90AA1 (1.00) HSP90AA1HSP90AB1MAOBSMN1; SMN2HPGD
SCHEMBL16628689 0.87 HSP90AA1 (0.77) HSP90AA1HSP90AB1ADORA3
SCHEMBL3096577 0.85 HSP90AA1 (1.00) HSP90AA1HSP90AB1MAOB
SCHEMBL3075275 0.82 HSP90AA1 (0.76) HSP90AA1HSP90AB1MAOBHPGD
SCHEMBL3089971 0.82 HSP90AA1 (0.76) HSP90AA1HSP90AB1MAOB
SCHEMBL3094007 0.81 HSP90AA1 (0.73) HSP90AA1HSP90AB1MAOB
SCHEMBL3086700 0.80 HSP90AA1 (0.79) HSP90AA1HSP90AB1MAOBSMN1; SMN2HPGD
SCHEMBL16628710 0.80 HSP90AA1 (0.76) HSP90AA1HSP90AB1MAOBSMN1; SMN2
SCHEMBL3094214 0.80 HSP90AA1 (0.73) HSP90AA1HSP90AB1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2164833-B1 Quinazolinamide derivatives useful for the treatment of tumour diseases MERCK PATENT GMBH (DE) 2015-04-15 EP claimed
EP-2164833-B1 Quinazolinamide derivatives useful for the treatment of tumour diseases MERCK PATENT GMBH (DE) 2015-04-15 EP disclosed