Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 12/20 | 0.73 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16628727 | 0.91 | HSP90AA1 (0.71) | HSP90AA1HSP90AB1MAPT | |
| SCHEMBL13180105 | 0.90 | HSP90AA1 (0.73) | HSP90AA1HSP90AB1 | |
| SCHEMBL3089971 | 0.89 | HSP90AA1 (0.76) | HSP90AA1HSP90AB1 | |
| SCHEMBL3099258 | 0.89 | HSP90AA1 (0.71) | HSP90AA1HSP90AB1 | |
| SCHEMBL12273440 | 0.89 | HSP90AA1 (0.71) | HSP90AA1HSP90AB1 | |
| SCHEMBL12273815 | 0.89 | HSP90AA1 (0.71) | HSP90AA1HSP90AB1 | |
| SCHEMBL27869702 | 0.88 | HSP90AA1 (0.67) | HSP90AA1HSP90AB1DPP8DPP9DPP7 | |
| SCHEMBL3087837 | 0.88 | HSP90AA1 (0.76) | HSP90AA1HSP90AB1DPP8DPP9DPP7 | |
| SCHEMBL13961635 | 0.88 | HSP90AA1 (0.69) | HSP90AA1HSP90AB1 | |
| SCHEMBL12273502 | 0.88 | HSP90AA1 (0.72) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164833-B1 | Quinazolinamide derivatives useful for the treatment of tumour diseases | MERCK PATENT GMBH (DE) | 2015-04-15 | — | — | EP | claimed |
| EP-2164833-B1 | Quinazolinamide derivatives useful for the treatment of tumour diseases | MERCK PATENT GMBH (DE) | 2015-04-15 | — | — | EP | disclosed |