Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 11/20 | 0.71 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1768003 | 0.92 | HSP90AA1 (0.66) | HSP90AA1HSP90AB1 | |
| SCHEMBL16628749 | 0.91 | HSP90AA1 (0.73) | HSP90AA1HSP90AB1MAPT | |
| SCHEMBL3099258 | 0.91 | HSP90AA1 (0.71) | HSP90AA1HSP90AB1 | |
| SCHEMBL13960641 | 0.90 | HSP90AA1 (0.70) | HSP90AA1HSP90AB1 | |
| SCHEMBL3094007 | 0.90 | HSP90AA1 (0.73) | HSP90AA1HSP90AB1 | |
| SCHEMBL3076546 | 0.89 | HSP90AA1 (0.69) | HSP90AA1HSP90AB1 | |
| SCHEMBL3088591 | 0.89 | HSP90AA1 (0.73) | HSP90AA1HSP90AB1MAPTALDH1A1MAPK1 | |
| SCHEMBL13180105 | 0.88 | HSP90AA1 (0.73) | HSP90AA1HSP90AB1 | |
| SCHEMBL27869742 | 0.88 | HSP90AA1 (0.66) | HSP90AA1HSP90AB1 | |
| SCHEMBL27869740 | 0.87 | HSP90AA1 (0.66) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164833-B1 | Quinazolinamide derivatives useful for the treatment of tumour diseases | MERCK PATENT GMBH (DE) | 2015-04-15 | — | — | EP | claimed |
| EP-2164833-B1 | Quinazolinamide derivatives useful for the treatment of tumour diseases | MERCK PATENT GMBH (DE) | 2015-04-15 | — | — | EP | disclosed |