Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 17/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | EBP | Q15125 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11705 | 0.93 | LIPE (0.64) | LIPEHDAC11EBP | |
| SCHEMBL11736 | 0.93 | LIPE (0.64) | LIPEHDAC11EBP | |
| SCHEMBL11060 | 0.84 | LIPE (0.53) | LIPEHDAC11EBP | |
| SCHEMBL744447 | 0.80 | LIPE (0.60) | LIPEHRH3EBP | |
| SCHEMBL12688337 | 0.78 | LIPE (0.60) | LIPEHRH3EBP | |
| SCHEMBL1589479 | 0.78 | LIPE (0.60) | LIPEHRH3EBP | |
| SCHEMBL11606 | 0.78 | LIPE (0.60) | LIPEHRH3EBP | |
| SCHEMBL11888 | 0.77 | LIPE (0.46) | LIPEHDAC11EBP | |
| SCHEMBL11643 | 0.77 | LIPE (0.59) | LIPEHRH3EBP | |
| SCHEMBL11778 | 0.77 | LIPE (0.62) | LIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488493-B1 | SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS HSL INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES | HOFFMANN LA ROCHE (CH) | 2015-04-15 | — | — | EP | disclosed |