Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 16/20 | 0.66 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16628849 | 1.00 | LIPE (0.66) | LIPEITGB3ITGA2BEGLN1 | |
| SCHEMBL16628699 | 0.89 | LIPE (0.53) | LIPEITGB3ITGA2BEGLN1 | |
| SCHEMBL16628700 | 0.89 | LIPE (0.53) | LIPEITGB3ITGA2BEGLN1 | |
| SCHEMBL10020 | 0.84 | LIPE (0.69) | LIPEITGB3ITGA2B | |
| SCHEMBL10336 | 0.84 | LIPE (0.65) | LIPEITGB3ITGA2B | |
| SCHEMBL10337 | 0.84 | LIPE (0.65) | LIPEITGB3ITGA2B | |
| SCHEMBL10019 | 0.84 | LIPE (0.69) | LIPEITGB3ITGA2B | |
| SCHEMBL5731 | 0.83 | LIPE (0.74) | LIPE | |
| SCHEMBL10267 | 0.83 | LIPE (0.64) | LIPEEGLN1 | |
| SCHEMBL12701947 | 0.83 | LIPE (0.64) | LIPEEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488493-B1 | SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS HSL INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES | HOFFMANN LA ROCHE (CH) | 2015-04-15 | — | — | EP | claimed |