Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 2/20 | 0.57 |
| ▸ | SMPD3 | Q9NY59 | 3/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 6/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL545331 | 0.80 | PIK3CG (0.61) | PIK3CGSMPD3PDE2AAXLHTR6 | |
| Ammonia Solution, Strong SCHEMBL14158423 | 0.78 | PIK3CG (0.59) | PIK3CGSMPD3PDE2AAXLHTR6 | |
| SCHEMBL13772943 | 0.77 | PIK3CG (0.57) | PIK3CGSMPD3PDE2AAXLHTR6 | |
| SCHEMBL21863418 | 0.77 | PIK3CG (0.57) | PIK3CGSMPD3PDE2AAXLHTR6 | |
| SCHEMBL31725153 | 0.77 | PIK3CG (0.57) | PIK3CGSMPD3PDE2AAXLHTR6 | |
| SCHEMBL31165797 | 0.77 | AXL (0.47) | PIK3CGSMPD3AXLHTR6CDK2 | |
| SCHEMBL15336872 | 0.77 | SMPD3 (0.47) | PIK3CGSMPD3AXLJAK2JAK3 | |
| SCHEMBL30852918 | 0.77 | PIK3CG (0.41) | PIK3CGSMPD3AXLHTR6CDK2 | |
| SCHEMBL23728667 | 0.77 | SMPD3 (0.51) | PIK3CGSMPD3AXLHTR6CDK2 | |
| SCHEMBL12146434 | 0.74 | PIK3CG (0.54) | PIK3CGSMPD3PDE2AAXLHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016054491-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. (US) | 2016-04-07 | — | — | WO | disclosed |
| WO-2015051244-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. (US) | 2015-04-09 | — | — | WO | disclosed |
| WO-2015051241-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. (US) | 2015-04-09 | — | — | WO | disclosed |