Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | HPGD | P15428 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15308503 | 0.82 | ALDH1A1 (0.34) | ALDH1A1HPGDSMN1; SMN2KDM4EKMT2A | |
| SCHEMBL19863964 | 0.80 | ALDH1A1 (0.31) | ALDH1A1HPGDSMN1; SMN2KDM4EKMT2A | |
| SCHEMBL20971707 | 0.77 | ALDH1A1 (0.31) | ALDH1A1HPGDSMN1; SMN2KDM4EKMT2A | |
| SCHEMBL16077836 | 0.76 | PLAT (0.47) | ALDH1A1HPGDKDM4EKMT2APOLB | |
| SCHEMBL15308601 | 0.76 | PLAT (0.47) | ALDH1A1HPGDSMN1; SMN2KDM4ERAB9A | |
| SCHEMBL5788398 | 0.73 | PLAT (0.34) | ALDH1A1HPGDSMN1; SMN2KDM4EKMT2A | |
| SCHEMBL26871058 | 0.71 | PLAT (0.30) | — | |
| SCHEMBL16535098 | 0.70 | EGLN2 (0.40) | — | |
| SCHEMBL16946611 | 0.68 | PLAT (0.56) | ALDH1A1SMN1; SMN2KDM4EKMT2AMAPT | |
| SCHEMBL26602716 | 0.67 | PARP1 (0.33) | ALDH1A1HPGDKDM4EMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016054491-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. (US) | 2016-04-07 | — | — | WO | disclosed |
| WO-2015051244-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. (US) | 2015-04-09 | — | — | WO | disclosed |
| WO-2015051241-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. (US) | 2015-04-09 | — | — | WO | disclosed |