Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GRN | P28799 | 1/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 3/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.35 |
| ▸ | LTK | P29376 | 2/20 | 0.35 |
| ▸ | CLK2 | P49760 | 2/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.35 |
| ▸ | PHGDH | O43175 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TERT | O14746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16450837 | 0.81 | KDM4E (0.40) | KDM4EGRNSORT1MEN1KMT2A | |
| SCHEMBL15059353 | 0.81 | GRN (0.58) | KDM4EGRNSORT1PHGDHMEN1 | |
| SCHEMBL17662696 | 0.80 | KDM4E (0.37) | KDM4EGRNSORT1PIM3PIM2 | |
| SCHEMBL2338097 | 0.79 | SMN1; SMN2 (0.46) | KDM4EGRNSORT1CDK8CCNC | |
| SCHEMBL3760854 | 0.79 | KDM4E (0.39) | KDM4EGRNSORT1CDK8CCNC | |
| SCHEMBL29092152 | 0.79 | PLA2G10 (0.49) | KDM4EGRNSORT1CDK8CCNC | |
| SCHEMBL24484133 | 0.78 | KDM4E (0.38) | KDM4EGRNSORT1CDK8CCNC | |
| SCHEMBL1196207 | 0.78 | KDM4E (0.38) | KDM4EGRNSORT1CDK8CCNC | |
| Hydrochloric Acid SCHEMBL5754005 | 0.78 | SMN1; SMN2 (0.44) | KDM4EGRNSORT1CDK8CCNC | |
| Hydrochloric Acid SCHEMBL4035308 | 0.78 | SMN1; SMN2 (0.44) | KDM4EGRNSORT1CDK8CCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112812128-B | Macrocyclic compounds as ALK and ROS modulators | 正大天晴药业集团股份有限公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-112812128-A | Macrocyclic compounds as ALK and ROS modulators | 正大天晴药业集团股份有限公司 | 2021-05-18 | — | — | CN | disclosed |
| WO-2015050989-A2 | MACROCYCLIC COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | CS THERAPEUTICS INC. (US) | 2015-04-09 | — | — | WO | disclosed |