SCHEMBL16629868

CCC(c1cc(C)n[nH]1)N(C)C(=O)c1ccc(C[C@@H]2CC[C@H]([C@H](O[Si](C)(C)C(C)(C)C)c3cccnc3)N2C(=O)OC(C)(C)C)cc1

nearest known ligand 0.32

Predicted protein targets (top 1)

	gene	UniProt	supporting neighbours	confidence
▸	GPR119	Q8TDV5	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL18017421	1.00	GPR119 (0.32)	GPR119
SCHEMBL16619846	0.90	—	—
SCHEMBL18210801	0.90	—	—
SCHEMBL16619849	0.90	—	—
SCHEMBL18210802	0.84	CETP (0.32)	—
SCHEMBL18017424	0.84	CETP (0.32)	—
SCHEMBL17986583	0.82	MAPT (0.37)	GPR119
SCHEMBL17986534	0.82	MAPT (0.37)	GPR119
SCHEMBL16619656	0.82	MAPT (0.37)	GPR119
SCHEMBL16619101	0.81	ADRB3 (0.35)	GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2015050798-A1	NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS	MERCK SHARP & DOHME CORP. (US)	2015-04-09	—	—	WO	disclosed