Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 3/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 6/20 | 0.40 |
| ▸ | JAK3 | P52333 | 4/20 | 0.39 |
| ▸ | STAT6 | P42226 | 2/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1662793 | 0.78 | PLK4 (0.46) | TTKPLK4BTKJAK3EGFR | |
| SCHEMBL1662994 | 0.77 | PLK4 (0.53) | TTKPLK4BTKJAK3JAK2 | |
| SCHEMBL671179 | 0.76 | STAT6 (0.54) | JAK3STAT6NTRK1SYKRPS6KA3 | |
| SCHEMBL1662386 | 0.76 | PLK4 (0.50) | TTKPLK4BTKJAK3JAK2 | |
| SCHEMBL1662982 | 0.75 | JAK3 (0.42) | PLK4HTR2AHTR2CBTKJAK3 | |
| SCHEMBL1662557 | 0.74 | JAK3 (0.41) | PLK4HTR2AHTR2CBTKJAK3 | |
| SCHEMBL12002573 | 0.73 | PLK4 (0.51) | TTKPLK4HTR2ABTKJAK3 | |
| SCHEMBL1662711 | 0.73 | JAK3 (0.42) | PLK4BTKJAK3EGFRJAK2 | |
| SCHEMBL13838181 | 0.73 | STAT6 (0.75) | JAK3STAT6JAK2RPS6KA3 | |
| SCHEMBL1663991 | 0.72 | JAK3 (0.39) | BTKJAK3EGFRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491039-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | Cellzome Limited (GB) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011048082-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2011-04-28 | — | — | WO | disclosed |