Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 3/20 | 0.45 |
| ▸ | BRAF | P15056 | 2/20 | 0.45 |
| ▸ | KRAS | P01116 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ARAF | P10398 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15289509 | 0.89 | RAF1 (0.43) | RAF1BRAFKRASLMNAMAPT | |
| SCHEMBL15289565 | 0.88 | RAF1 (0.63) | RAF1BRAFKRASMAPTMEN1 | |
| SCHEMBL16632505 | 0.85 | KDR (0.46) | RAF1BRAFKRASLMNAABL1 | |
| SCHEMBL15289533 | 0.83 | ALDH1A1 (0.43) | LMNAALDH1A1 | |
| SCHEMBL16632381 | 0.83 | KDR (0.39) | RAF1BRAFKRASLMNAMAPT | |
| SCHEMBL31032185 | 0.81 | ABL1 (0.42) | MEN1HTTKMT2AABL1 | |
| SCHEMBL16632300 | 0.81 | RAF1 (0.53) | RAF1BRAFKRASMAPTMEN1 | |
| SCHEMBL15272707 | 0.80 | KDR (0.47) | RAF1BRAFKRASLMNAMAPT | |
| SCHEMBL15289515 | 0.78 | BRAF (0.43) | RAF1BRAFKRASLMNAABL1 | |
| SCHEMBL15289530 | 0.78 | ALDH1A1 (0.41) | RAF1BRAFKRASARAFALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9187474-B2 | Raf inhibitor compounds | DECIPHERA PHARMACEUTICALS, LLC (US) | 2015-11-17 | — | — | US | disclosed |
| US-20150105367-A1 | RAF INHIBITOR COMPOUNDS | DECIPHERA PHARMACEUTICALS, LLC | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105367-A1 | RAF INHIBITOR COMPOUNDS | BRAF, RAF1, NRAS | RAF1 2/4885BRAF 1/4885KRAS 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.