Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.47 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MPL | P40238 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16633138 | 0.87 | PARP1 (0.61) | MAPTPARP1LMNATSHRMAPK1 | |
| SCHEMBL12301000 | 0.86 | MAPT (0.58) | MAPTPARP1LMNATSHRMAPK1 | |
| SCHEMBL12248431 | 0.84 | MAPT (0.64) | MAPTPARP1LMNATSHRMAPK1 | |
| SCHEMBL12249029 | 0.82 | LMNA (0.63) | MAPTPARP1LMNATSHRMAPK1 | |
| SCHEMBL14992339 | 0.82 | MAPT (0.62) | MAPTPARP1LMNATSHRMAPK1 | |
| SCHEMBL16632799 | 0.82 | MAPT (0.66) | MAPTPARP1LMNATSHRMAPK1 | |
| SCHEMBL16632785 | 0.82 | MAPT (0.61) | MAPTPARP1LMNATSHRMAPK1 | |
| SCHEMBL2381353 | 0.82 | MAPT (0.61) | MAPTPARP1LMNATSHRMAPK1 | |
| SCHEMBL16633072 | 0.81 | PARP1 (0.54) | MAPTPARP1LMNATSHRMAPK1 | |
| SCHEMBL16640659 | 0.81 | MAPT (0.52) | MAPTPARP1LMNATSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670197-B2 | Small molecule modifiers of the Hec1-Nek2 interaction in G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-06-06 | — | — | US | disclosed |
| US-9670197-B2 | Small molecule modifiers of the Hec1-Nek2 interaction in G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-06-06 | — | — | US | disclosed |
| US-20160318918-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-11-03 | — | — | US | disclosed |
| US-20160318918-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-11-03 | — | — | US | disclosed |
| US-9422275-B2 | Small molecule modifiers of the HEC1-NEK2 interaction in G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-08-23 | — | — | US | disclosed |
| US-9422275-B2 | Small molecule modifiers of the HEC1-NEK2 interaction in G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-08-23 | — | — | US | disclosed |
| US-20150105391-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-04-16 | — | — | US | disclosed |
| US-20150105391-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318918-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | NR2E1, NEK4, NCOR2 | MAPT 4133/4885PARP1 1443/4885LMNA 3240/4885 |
| US-20150105391-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | NR2E1, NEK4, NCOR2 | MAPT 4133/4885PARP1 1443/4885LMNA 3240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.