Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 known ✓ | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 known ✓ | P49810 | 1/20 | 0.34 |
| ▸ | APH1B known ✓ | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN known ✓ | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A known ✓ | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN known ✓ | Q9NZ42 | 1/20 | 0.34 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.48 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.46 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2476869 | 0.98 | — | — | |
| Hydrochloric Acid SCHEMBL27472049 | 0.96 | UHRF1 (0.48) | UHRF1SMARCA2SMARCA4HDAC3HDAC1 | |
| SCHEMBL883728 | 0.77 | — | — | |
| SCHEMBL10138666 | 0.76 | — | — | |
| SCHEMBL27629951 | 0.76 | — | — | |
| SCHEMBL2885926 | 0.76 | — | — | |
| SCHEMBL17621230 | 0.74 | SCN9A (0.51) | UHRF1SMARCA2SMARCA4HDAC3HDAC1 | |
| SCHEMBL24004058 | 0.74 | KDM4E (0.56) | HDAC3HDAC1HDAC2HDAC6MEN1 | |
| SCHEMBL1759892 | 0.73 | GOT1 (0.37) | SMARCA2SMARCA4KDM4E | |
| SCHEMBL19223206 | 0.72 | UHRF1 (0.46) | UHRF1SMARCA2SMARCA4HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296720-B2 | Carboxamide-substituted heteroaryl-pyrazoles and the use thereof | AICURIS GMBH & CO. KG (DE) | 2016-03-29 | — | — | US | disclosed |
| US-20150105388-A1 | CARBOXAMIDE-SUBSTITUTED HETEROARYL-PYRAZOLES AND THE USE THEREOF | AICURIS GMBH & CO. KG (DE) | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105388-A1 | CARBOXAMIDE-SUBSTITUTED HETEROARYL-PYRAZOLES AND THE USE THEREOF | PAICS, AADAC, TPMT | PSEN1 2153/4885PSEN2 2184/4885APH1B 841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.