Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.73 |
| ▸ | CASP7 | P55210 | 1/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.73 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.69 |
| ▸ | MEN1 | O00255 | 5/20 | 0.69 |
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | GAA | P10253 | 2/20 | 0.69 |
| ▸ | PKM | P14618 | 1/20 | 0.69 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.61 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.61 |
| ▸ | MYC | P01106 | 1/20 | 0.58 |
| ▸ | MAX | P61244 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | GSK3A | P49840 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16634580 | 1.00 | TDP1 (0.73) | TDP1ALDH1A1MAPK1CASP7L3MBTL1 | |
| SCHEMBL3914644 | 0.89 | MAPK1 (0.71) | TDP1ALDH1A1MAPK1CASP7L3MBTL1 | |
| SCHEMBL11506844 | 0.87 | ALDH1A1 (0.89) | TDP1ALDH1A1MAPK1CASP7L3MBTL1 | |
| SCHEMBL11327756 | 0.86 | KMT2A (0.68) | TDP1ALDH1A1MAPK1CASP7L3MBTL1 | |
| SCHEMBL27481715 | 0.85 | MAPK1 (0.65) | TDP1ALDH1A1MAPK1CASP7L3MBTL1 | |
| SCHEMBL6677786 | 0.85 | MAPK1 (0.65) | TDP1ALDH1A1MAPK1CASP7L3MBTL1 | |
| SCHEMBL31333098 | 0.85 | TDP1 (1.00) | TDP1ALDH1A1MAPK1CASP7L3MBTL1 | |
| SCHEMBL230292 | 0.85 | TDP1 (1.00) | TDP1ALDH1A1MAPK1CASP7L3MBTL1 | |
| SCHEMBL30839074 | 0.84 | AKR1C3 (0.72) | TDP1ALDH1A1MAPK1CASP7L3MBTL1 | |
| SCHEMBL3497986 | 0.84 | MAPT (0.64) | TDP1ALDH1A1MAPK1CASP7L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |