Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 14/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | PYGL | P06737 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16634773 | 0.91 | RORC (0.48) | RORCLMNAMAPK1HTTRAB9A | |
| SCHEMBL16634781 | 0.82 | RORC (0.55) | RORCCYP2C9CYP3A4 | |
| SCHEMBL16634824 | 0.78 | RORC (0.51) | RORCCYP2C9CYP3A4 | |
| SCHEMBL16634638 | 0.77 | RORC (0.50) | RORCCYP2C9CYP3A4 | |
| SCHEMBL16634596 | 0.77 | RORC (0.61) | RORCCYP2C9CYP3A4 | |
| SCHEMBL16634869 | 0.76 | RORC (0.55) | RORCCYP2C9CYP3A4 | |
| SCHEMBL16634653 | 0.76 | RORC (0.60) | RORCCYP2C9CYP3A4 | |
| SCHEMBL16634761 | 0.75 | RORC (0.58) | RORCCYP2C9CYP3A4 | |
| SCHEMBL16634752 | 0.74 | RORC (0.56) | RORCCYP2C9CYP3A4 | |
| SCHEMBL16634679 | 0.72 | RORC (0.46) | RORCCYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | claimed |
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |