Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 2/20 | 0.31 |
| ▸ | GRN | P28799 | 1/20 | 0.30 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12119372 | 1.00 | CA1 (0.35) | CA1CA2CA7HTTLMNA | |
| SCHEMBL24176580 | 0.81 | TDP1 (0.39) | CA1CA2CA7LMNARIPK1 | |
| SCHEMBL29463584 | 0.80 | CA1 (0.39) | CA1CA2CA7RIPK1CNR2 | |
| SCHEMBL25590149 | 0.80 | CA1 (0.39) | CA1CA2CA7RIPK1ALDH1A1 | |
| SCHEMBL4344360 | 0.80 | CA1 (0.39) | CA1CA2CA7RIPK1CNR2 | |
| SCHEMBL25592327 | 0.80 | CA1 (0.39) | CA1CA2CA7RIPK1ALDH1A1 | |
| SCHEMBL18219784 | 0.80 | CA1 (0.39) | CA1CA2CA7RIPK1ALDH1A1 | |
| SCHEMBL13299878 | 0.79 | HTT (0.36) | HTTLMNARIPK1MEN1ALDH1A1 | |
| SCHEMBL12119396 | 0.79 | HTT (0.36) | HTTLMNARIPK1MEN1ALDH1A1 | |
| SCHEMBL21789729 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11970512-B2 | Amphotericin B derivatives with improved therapeutic index | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2024-04-30 | — | — | US | disclosed |
| CN-110407898-B | Amphotericin B derivatives with improved therapeutic index | 伊利诺伊大学评议会 | 2023-12-01 | — | — | CN | disclosed |
| US-20220056066-A1 | AMPHOTERICIN B DERIVATIVES WITH IMPROVED THERAPEUTIC INDEX | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2022-02-24 | — | — | US | disclosed |
| US-11117920-B2 | Amphotericin B derivatives with improved therapeutic index | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2021-09-14 | — | — | US | disclosed |
| US-11028114-B2 | Amphotericin B derivatives with improved therapeutic index | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2021-06-08 | — | — | US | disclosed |
| US-20190345187-A1 | AMPHOTERICIN B DERIVATIVES WITH IMPROVED THERAPEUTIC INDEX | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2019-11-14 | — | — | US | disclosed |
| US-10323057-B2 | Amphotericin B derivatives with improved therapeutic index | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2019-06-18 | — | — | US | disclosed |
| US-20180273571-A1 | CONCISE SYNTHESIS OF UREA DERIVATIVES OF AMPHOTERICIN B | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2018-09-27 | — | — | US | disclosed |
| EP-3055030-B1 | AMPHOTERICIN B DERIVATIVES WITH IMPROVED THERAPEUTIC INDEX | UNIV ILLINOIS (US) | 2018-05-02 | — | — | EP | disclosed |
| EP-3242554-A1 | CONCISE SYNTHESIS OF UREA DERIVATIVES OF AMPHOTERICIN B | The Board of Trustees of the University of Illionis (US) | 2017-11-15 | — | — | EP | disclosed |
| EP-3055030-A1 | AMPHOTERICIN B DERIVATIVES WITH IMPROVED THERAPEUTIC INDEX | The Board of Trustees of the University of Illinois (US) | 2016-08-17 | — | — | EP | disclosed |
| US-20160215012-A1 | AMPHOTERICIN B DERIVATIVES WITH IMPROVED THERAPEUTIC INDEX | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (IL) | 2016-07-28 | — | — | US | disclosed |
| WO-2016112243-A1 | UREA DERIVATIVES OF AMPHOTERICIN B DERIVED FROM SECONDARY AMINES | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2016-07-14 | — | — | WO | disclosed |
| WO-2016112260-A1 | CONCISE SYNTHESIS OF UREA DERIVATIVES OF AMPHOTERICIN B | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2016-07-14 | — | — | WO | disclosed |
| WO-2016040779-A1 | UREA DERIVATIVES OF POLYENE MACROLIDE ANTIBIOTICS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2016-03-17 | — | — | WO | disclosed |
| WO-2015054148-A1 | AMPHOTERICIN B DERIVATIVES WITH IMPROVED THERAPEUTIC INDEX | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2015-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220056066-A1 | AMPHOTERICIN B DERIVATIVES WITH IMPROVED THERAPEUTIC INDEX | C9, AMPD3, C5 | CA1 3394/4885CA2 3877/4885CA7 941/4885 |
| US-20160215012-A1 | AMPHOTERICIN B DERIVATIVES WITH IMPROVED THERAPEUTIC INDEX | C9, AMPD3, C5 | CA1 3394/4885CA2 3877/4885CA7 941/4885 |
| US-20180273571-A1 | CONCISE SYNTHESIS OF UREA DERIVATIVES OF AMPHOTERICIN B | NAT10, CPS1, ERG28 | CA1 2918/4885CA2 2819/4885CA7 664/4885 |
| US-20190345187-A1 | AMPHOTERICIN B DERIVATIVES WITH IMPROVED THERAPEUTIC INDEX | C9, AMPD3, C5 | CA1 3394/4885CA2 3877/4885CA7 941/4885 |
| US-10323057-B2 | Amphotericin B derivatives with improved therapeutic index | C9, AMPD3, C5 | CA1 3394/4885CA2 3877/4885CA7 941/4885 |
| US-11028114-B2 | Amphotericin B derivatives with improved therapeutic index | C9, AMPD3, C5 | CA1 3394/4885CA2 3877/4885CA7 941/4885 |
| US-11117920-B2 | Amphotericin B derivatives with improved therapeutic index | C9, AMPD3, C5 | CA1 3394/4885CA2 3877/4885CA7 941/4885 |
| US-11970512-B2 | Amphotericin B derivatives with improved therapeutic index | C9, AMPD3, C5 | CA1 3394/4885CA2 3877/4885CA7 941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.