Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 7/20 | 0.47 |
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SMO | Q99835 | 2/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1663556 | 0.91 | MEN1 (0.60) | MEN1KMT2ANPC1RAB9ATDP1 | |
| SCHEMBL1666277 | 0.86 | NPC1 (0.48) | MEN1KMT2ANPC1RAB9ATDP1 | |
| SCHEMBL1666799 | 0.85 | MAPT (0.53) | MEN1KMT2ANPC1RAB9ATDP1 | |
| SCHEMBL1664235 | 0.83 | MAPT (0.49) | MEN1KMT2ANPC1RAB9ATDP1 | |
| SCHEMBL1665083 | 0.83 | SMO (0.52) | MEN1KMT2ASMONR3C1MAPK8 | |
| SCHEMBL1666114 | 0.82 | MAPT (0.51) | MEN1KMT2ANPC1RAB9ATDP1 | |
| SCHEMBL1665038 | 0.82 | MAPT (0.49) | MEN1KMT2ANPC1RAB9ATDP1 | |
| SCHEMBL6125796 | 0.82 | MAPT (0.50) | MEN1KMT2ANPC1RAB9ATDP1 | |
| SCHEMBL1666123 | 0.82 | NPC1 (0.48) | MEN1KMT2ANPC1RAB9ATDP1 | |
| SCHEMBL1664395 | 0.82 | MAPT (0.50) | MEN1KMT2ANPC1RAB9ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |