Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | CRACR2A | Q9BSW2 | 2/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665085 | 0.94 | SMO (0.53) | SMOMAPK1MAPK8MAPK10MAOB | |
| SCHEMBL1665249 | 0.90 | SMO (0.54) | SMOMAPK1MAPK8MAPK10MAOB | |
| SCHEMBL1665395 | 0.89 | SMO (0.51) | SMOMAPK1MAPK8MAPK10MAOB | |
| SCHEMBL1665254 | 0.84 | SMO (0.57) | SMOMAPK8MAPK10MAOBNR3C1 | |
| SCHEMBL1666461 | 0.84 | MAPT (0.50) | MAPK8MAPK10MAOBCRACR2AGAA | |
| SCHEMBL13964701 | 0.83 | MAOB (0.54) | SMOMAPK8MAPK10MAOBGAA | |
| SCHEMBL1665396 | 0.83 | SMO (0.53) | SMOMAPK8MAPK10MAOBNR3C1 | |
| SCHEMBL1663552 | 0.83 | MEN1 (0.47) | SMOMAPK8MAPK10NR3C1MEN1 | |
| SCHEMBL27937046 | 0.82 | MAOB (0.58) | SMOMAOBNR3C1MEN1KMT2A | |
| SCHEMBL1664622 | 0.82 | SMO (0.54) | SMOMAPK8MAPK10MAOBNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |