⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1663568 | 1.00 | — | — | |
| SCHEMBL21780104 | 1.00 | — | — | |
| SCHEMBL21914559 | 0.76 | — | — | |
| SCHEMBL21780128 | 0.73 | — | — | |
| SCHEMBL22216363 | 0.72 | — | — | |
| SCHEMBL1295543 | 0.71 | MAOB (0.73) | — | |
| SCHEMBL1294796 | 0.71 | MAOB (0.73) | — | |
| SCHEMBL23369948 | 0.71 | MAOB (0.43) | — | |
| SCHEMBL9657580 | 0.71 | AOC2 (0.43) | — | |
| SCHEMBL23369947 | 0.71 | MAOB (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011047412-A1 | TYROSINE AND L-DOPA FOR REDUCING L-DOPA INCORPORATION INTO PROTEINS | THE HEART RESEARCH INSTITUTE LTD (AU) | 2011-04-28 | — | — | WO | disclosed |
| US-20100247543-A1 | TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES | ORYZON GENOMICS, S.A. (ES) | 2010-09-30 | — | — | US | disclosed |
| EP-2195029-A2 | TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES | Oryzon Genomics SA (ES) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009027349-A2 | TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES | ORYZON GENOMICS SA (ES) | 2009-03-05 | — | — | WO | disclosed |
| EP-0224924-B1 | NON-AROMATIC FLUORALLYLAMINE MAO INHIBITORS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-01-22 | — | — | EP | disclosed |
| US-4916151-A | ADMINISTERING FLUOROALLYLAMINE, L-DOPA AND DICARBOXYLASE INHIBITOR | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-04-10 | — | — | US | disclosed |
| EP-0224924-A2 | Non-aromatic fluorallylamine MAO inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-06-10 | — | — | EP | disclosed |
| US-4650907-A | MONOAMINE OXIDASE, ANTIDEPRESSANTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-03-17 | — | — | US | disclosed |