Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 20/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 19/20 | 0.71 |
| ▸ | HDAC2 | Q92769 | 19/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 19/20 | 0.71 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16632337 | 0.83 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC6HDAC8 | |
| SCHEMBL16636217 | 0.83 | HDAC3 (0.72) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL22874120 | 0.79 | HDAC3 (0.74) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL16632298 | 0.79 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL16644607 | 0.77 | HDAC1 (0.79) | HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL16632393 | 0.77 | HDAC3 (0.77) | HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL16636826 | 0.73 | HDAC3 (0.76) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL22874181 | 0.73 | HDAC3 (0.77) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL4730872 | 0.73 | HDAC6 (1.00) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| Hydrochloric Acid SCHEMBL28602304 | 0.72 | HDAC6 (0.69) | HDAC1HDAC3HDAC2HDAC6HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055299-A1 | PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | Acetylon Pharmaceuticals, Inc. (US) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015054474-A1 | PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | ACETYLON PHARMACEUTICALS, INC. (US) | 2015-04-16 | — | — | WO | disclosed |