Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 8/20 | 0.37 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.36 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.36 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16636946 | 0.91 | IL2 (0.46) | IL2STIM1ORAI1ORAI2TP53 | |
| SCHEMBL16636906 | 0.88 | IL2 (0.38) | IL2STIM1ORAI1ORAI2SCN5A | |
| SCHEMBL16636486 | 0.84 | IL2 (0.37) | IL2STIM1ORAI1SMN1; SMN2KDM4E | |
| SCHEMBL16636432 | 0.84 | IL2 (0.39) | IL2STIM1ORAI1ORAI2RAB9A | |
| SCHEMBL16636692 | 0.82 | SMN1; SMN2 (0.46) | IL2STIM1ORAI1ORAI2SMN1; SMN2 | |
| SCHEMBL16636612 | 0.81 | IL2 (0.36) | IL2STIM1ORAI1ORAI2SMN1; SMN2 | |
| SCHEMBL16636701 | 0.79 | IL2 (0.42) | IL2STIM1ORAI1SMN1; SMN2KDM4E | |
| SCHEMBL16636685 | 0.79 | IL2 (0.48) | IL2STIM1ORAI1ORAI2TP53 | |
| SCHEMBL16636723 | 0.78 | NPC1 (0.39) | IL2SMN1; SMN2KDM4EHSD17B10NPC1 | |
| SCHEMBL16636506 | 0.77 | SMN1; SMN2 (0.40) | STIM1ORAI1SMN1; SMN2KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015054283-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2015-04-16 | — | — | WO | disclosed |