SCHEMBL16636976

SCHEMBL16636976

C=CC(=O)N1CCC(Nc2n[nH]c3cc(Cl)c(-c4ccccc4Cl)cc23)CC1

nearest known ligand 0.51

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
FGFR4 P22455 1/20 0.51
MCHR1 Q99705 3/20 0.44
CDK14 O94921 2/20 0.43
CCNY Q8ND76 2/20 0.43
CNR1 P21554 1/20 0.43
JAK3 P52333 2/20 0.42
EGFR P00533 2/20 0.42
BTK Q06187 2/20 0.42
KRAS P01116 3/20 0.42
GSK3B P49841 2/20 0.42
PAK1 Q13153 2/20 0.42
KDM5B Q9UGL1 1/20 0.41
CDK1 P06493 1/20 0.41
CDK2 P24941 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29766081 1.00 FGFR4 (0.51) FGFR4MCHR1CDK14CCNYCNR1
SCHEMBL21302112 0.93 MCHR1 (0.45) FGFR4MCHR1CNR1GSK3BPAK1
SCHEMBL17833927 0.91 GSK3B (0.53) FGFR4MCHR1CNR1JAK3EGFR
SCHEMBL17026599 0.85 PRKAB2 (0.44) FGFR4CDK14CCNYJAK3BTK
SCHEMBL16646871 0.81 KRAS (0.51) JAK3KRAS
SCHEMBL16646903 0.81 EGFR (0.55) CNR1EGFRBTKKRASPAK1
SCHEMBL16636882 0.80 CYP1A2 (0.53) MCHR1GSK3BCDK1CDK2
SCHEMBL16646944 0.71 EGFR (0.51) JAK3EGFR
SCHEMBL29765798 0.71 KRAS (0.48) EGFRKRAS
SCHEMBL16636897 0.71 KRAS (0.48) EGFRKRAS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3193851-B1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC (US) 2020-10-21 EP claimed
EP-3055290-B1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2019-10-02 EP claimed
US-12234244-B2 Substituted piperazines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2025-02-25 US disclosed
US-20240352028-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2024-10-24 US disclosed
US-20240043441-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2024-02-08 US disclosed
US-11878985-B2 Substituted quinazolines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2024-01-23 US disclosed
US-20230303586-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-09-28 US disclosed
US-20230303586-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-09-28 US disclosed
US-20230303586-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-09-28 US disclosed
US-20230212183-A9 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-07-06 US disclosed
US-20230212183-A9 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2023-07-06 US disclosed
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC 2016-06-16 US disclosed
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC 2016-06-16 US disclosed
WO-2016044772-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC (US) 2016-03-24 WO disclosed
WO-2016044772-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER ARAXES PHARMA LLC (US) 2016-03-24 WO disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
WO-2015054572-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2015-04-16 WO disclosed
WO-2015054572-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2015-04-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12234244-B2 Substituted piperazines as inhibitors of KRAS G12C KRAS, NRAS, HRAS FGFR4 2507/4885MCHR1 4190/4885CDK14 1490/4885
US-11878985-B2 Substituted quinazolines as inhibitors of KRAS G12C KRAS, NRAS, HRAS FGFR4 3084/4885MCHR1 3915/4885CDK14 479/4885
US-20240352028-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS FGFR4 3084/4885MCHR1 3915/4885CDK14 479/4885
US-20150239900-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS FGFR4 2792/4885MCHR1 2974/4885CDK14 938/4885
US-20230212183-A9 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS FGFR4 2792/4885MCHR1 2974/4885CDK14 938/4885
US-20240043441-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS FGFR4 2792/4885MCHR1 2974/4885CDK14 938/4885
US-20230303586-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS FGFR4 2792/4885MCHR1 2974/4885CDK14 938/4885
US-20160166571-A1 COMBINATION THERAPIES FOR TREATMENT OF CANCER KRAS, TP53, HRAS FGFR4 312/4885MCHR1 4539/4885CDK14 719/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.