SCHEMBL16637058

SCHEMBL16637058

Oc1ccccc1Cc1cc(I)ccc1Cl

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSPA5 P11021 2/20 0.55
ALDH1A1 P00352 1/20 0.42
KEAP1 Q14145 1/20 0.42
HSP90AA1 P07900 3/20 0.40
HIF1A Q16665 3/20 0.40
IDO1 P14902 2/20 0.40
MEN1 O00255 2/20 0.40
CYP3A4 P08684 2/20 0.40
HPGD P15428 2/20 0.40
ALOX15 P16050 2/20 0.40
KMT2A Q03164 2/20 0.40
SLC22A1 O15245 1/20 0.40
USP2 O75604 1/20 0.40
LMNA P02545 1/20 0.40
MAPT P10636 1/20 0.40
HSPD1 P10809 1/20 0.40
ALOX12 P18054 1/20 0.40
CASP1 P29466 1/20 0.40
HTT P42858 1/20 0.40
BLM P54132 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13481999 0.85 HSPA5 (0.64) HSPA5KEAP1HSP90AA1HIF1AIDO1
SCHEMBL7101509 0.83 HSPA5 (0.73) HSPA5ALDH1A1KEAP1HSP90AA1HIF1A
SCHEMBL26123823 0.75 HIF1A (0.54) HSPA5HSP90AA1HIF1AIDO1MEN1
SCHEMBL10470450 0.74 HSPA5 (0.64) HSPA5ALDH1A1KEAP1HSP90AA1HIF1A
SCHEMBL29357407 0.74 HSPA5 (1.00) HSPA5ALDH1A1KEAP1HIF1AIDO1
SCHEMBL49745 0.74 HSPA5 (1.00) HSPA5ALDH1A1KEAP1HIF1AIDO1
SCHEMBL15303195 0.74 MEN1 (0.46) KEAP1IDO1MEN1CYP3A4KMT2A
SCHEMBL2305654 0.73 HSPA5 (0.61) HSPA5ALDH1A1KEAP1HSP90AA1HIF1A
SCHEMBL11815038 0.72 HSPA5 (0.46) HSPA5KEAP1HSP90AA1HIF1AIDO1
SCHEMBL29839938 0.72 HSPA5 (0.94) HSPA5ALDH1A1KEAP1HIF1AIDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3055281-B1 PREPARATION OF HYDROXY-BENZYLBENZENE DERIVATIVES THERACOS SUB LLC (US) 2020-01-08 EP disclosed
EP-3055281-A1 PREPARATION OF HYDROXY-BENZYLBENZENE DERIVATIVES Theracos Sub, LLC (US) 2016-08-17 EP disclosed
WO-2015051597-A1 PREPARATION OF HYDROXY-BENZYLBENZENE DERIVATIVES THERACOS, INC. (US) 2015-04-16 WO disclosed