Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHF8 | Q9UPP1 | 6/20 | 0.56 |
| ▸ | KDM2A | Q9Y2K7 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | KDM5C | P41229 | 4/20 | 0.56 |
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.53 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.53 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.52 |
| ▸ | KDM6B | O15054 | 2/20 | 0.52 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.47 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.47 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL367246 | 0.83 | OR51E2 (0.77) | PHF8KDM2AKDM4EKDM5COR51E2 | |
| Succinic Acid SCHEMBL6597777 | 0.83 | OR51E2 (0.77) | PHF8KDM2AKDM4EKDM5COR51E2 | |
| Succinic Acid SCHEMBL28253755 | 0.80 | OR51E2 (0.71) | PHF8KDM2AKDM4EKDM5COR51E2 | |
| Succinic Acid SCHEMBL28253757 | 0.80 | OR51E2 (0.71) | PHF8KDM2AKDM4EKDM5COR51E2 | |
| SCHEMBL4979808 | 0.79 | PHF8 (0.56) | PHF8KDM2AKDM4EKDM5COR51E2 | |
| SCHEMBL4977396 | 0.78 | PHF8 (0.57) | PHF8KDM2AKDM4EKDM5COR51E2 | |
| SCHEMBL28461081 | 0.78 | PHF8 (0.57) | PHF8KDM2AKDM4EKDM5COR51E2 | |
| SCHEMBL17232600 | 0.77 | PHF8 (0.50) | PHF8KDM2AKDM4EKDM5COR51E2 | |
| SCHEMBL4977758 | 0.75 | PHF8 (0.52) | PHF8KDM2AKDM4EKDM5COR51E2 | |
| SCHEMBL4978244 | 0.75 | PHF8 (0.52) | PHF8KDM2AKDM4EKDM5COR51E2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10167365-B2 | Polymer and composition | DSM IP ASSETS B.V. (NL) | 2019-01-01 | — | — | US | disclosed |
| EP-3055340-B1 | POLYMER AND COMPOSITION | DSM IP ASSETS BV (NL) | 2017-11-22 | — | — | EP | disclosed |
| US-20160237213-A1 | POLYMER AND COMPOSITION | COVESTRO (NETHERLANDS) B.V. (NL) | 2016-08-18 | — | — | US | disclosed |
| EP-3055340-A1 | POLYMER AND COMPOSITION | DSM IP Assets B.V. (NL) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015052342-A1 | POLYMER AND COMPOSITION | DSM IP ASSETS B.V. (NL) | 2015-04-16 | — | — | WO | disclosed |