Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 13/20 | 0.55 |
| ▸ | MEN1 | O00255 | 12/20 | 0.55 |
| ▸ | MAPT | P10636 | 12/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 9/20 | 0.50 |
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.50 |
| ▸ | GAA | P10253 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.50 |
| ▸ | RELA | Q04206 | 4/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2362037 | 0.72 | NPC1 (0.49) | KMT2AMEN1MAPTLMNARAB9A | |
| SCHEMBL16637975 | 0.71 | MAPT (0.49) | KMT2AMEN1MAPTLMNARAB9A | |
| SCHEMBL7756093 | 0.71 | MAPT (1.00) | KMT2AMEN1MAPTLMNAPSMD14 | |
| SCHEMBL9668497 | 0.70 | MAPT (0.54) | KMT2AMEN1MAPTLMNAPSMD14 | |
| SCHEMBL9666910 | 0.69 | MAPT (0.52) | KMT2AMEN1MAPTLMNAPSMD14 | |
| SCHEMBL9788042 | 0.69 | MAPT (0.56) | KMT2AMEN1MAPTLMNAPSMD14 | |
| SCHEMBL2879032 | 0.67 | RAB9A (0.60) | KMT2AMEN1MAPTLMNARAB9A | |
| SCHEMBL4479462 | 0.67 | EGFR (0.64) | KMT2AMEN1MAPTLMNAPSMD14 | |
| SCHEMBL15331990 | 0.66 | MEN1 (1.00) | KMT2AMEN1MAPTLMNAPSMD14 | |
| SCHEMBL5108536 | 0.66 | ADORA2A (1.00) | KMT2AMEN1MAPTADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055315-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. Hoffmann-La Roche AG (CH) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015052226-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |