Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 19/20 | 0.44 |
| ▸ | CTSB | P07858 | 9/20 | 0.44 |
| ▸ | CTSS | P25774 | 9/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16636455 | 0.84 | CTSK (0.58) | CTSKCTSBCTSSJAK2JAK1 | |
| SCHEMBL16644703 | 0.84 | CTSK (0.58) | CTSKCTSBCTSSJAK2JAK1 | |
| SCHEMBL18010286 | 0.84 | CTSK (0.51) | CTSKCTSBCTSSJAK2JAK1 | |
| SCHEMBL16636453 | 0.84 | CTSK (0.51) | CTSKCTSBCTSSJAK2JAK1 | |
| SCHEMBL16635831 | 0.78 | HPGD (0.43) | CTSKCTSBCTSSCTSLJAK2 | |
| SCHEMBL16636287 | 0.78 | HPGD (0.43) | CTSKCTSBCTSSCTSLJAK2 | |
| SCHEMBL16636027 | 0.78 | HPGD (0.43) | CTSKCTSBCTSSCTSLJAK2 | |
| SCHEMBL24018997 | 0.76 | CTSK (0.44) | CTSKCTSBCTSSJAK2JAK1 | |
| SCHEMBL24018946 | 0.75 | CTSK (0.45) | CTSKCTSBCTSSJAK2JAK1 | |
| SCHEMBL24018942 | 0.74 | CTSK (0.46) | CTSKCTSBCTSSCTSLJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051479-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-04-16 | — | — | WO | claimed |