Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 3/20 | 0.64 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.60 |
| ▸ | MAOB | P27338 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 2/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.49 |
| ▸ | NSD2 | O96028 | 1/20 | 0.49 |
| ▸ | AS3MT | Q9HBK9 | 1/20 | 0.49 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5386440 | 0.91 | TTK (0.72) | TTKNTRK1MAOBMAPTMAOA | |
| SCHEMBL627903 | 0.84 | TTK (0.59) | TTKNTRK1MAOBMAPTMAOA | |
| SCHEMBL19149769 | 0.79 | NTRK1 (0.53) | TTKNTRK1IKBKEFGFR4MKNK1 | |
| SCHEMBL12282759 | 0.78 | TTK (1.00) | TTKMAPK8 | |
| SCHEMBL17982284 | 0.78 | TTK (0.55) | TTKNTRK1MAOBMAPTMAOA | |
| SCHEMBL2574384 | 0.78 | TTK (0.55) | TTKNTRK1MAOBMAPTMAOA | |
| SCHEMBL8877124 | 0.78 | TTK (0.55) | TTKNTRK1MAOBMAPTMAOA | |
| SCHEMBL1336392 | 0.78 | TTK (0.55) | TTKNTRK1MAOBMAPTMAOA | |
| SCHEMBL3918554 | 0.77 | ITK (0.60) | TTKNTRK1 | |
| SCHEMBL15064621 | 0.77 | PRMT5 (0.55) | TTKNTRK1IKBKEPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |