Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 18/20 | 0.75 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.54 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10230034 | 0.86 | EGLN1 (1.00) | EGLN1 | |
| SCHEMBL16638699 | 0.86 | EGLN1 (0.77) | EGLN1TRIM58HTR3AHRH4 | |
| SCHEMBL10227906 | 0.75 | EGLN1 (1.00) | EGLN1 | |
| SCHEMBL622171 | 0.74 | EGLN1 (1.00) | EGLN1 | |
| SCHEMBL621862 | 0.73 | EGLN1 (1.00) | EGLN1 | |
| SCHEMBL15899665 | 0.73 | EGLN1 (0.79) | EGLN1 | |
| SCHEMBL621381 | 0.72 | EGLN1 (1.00) | EGLN1 | |
| SCHEMBL622141 | 0.71 | EGLN1 (1.00) | EGLN1 | |
| SCHEMBL622121 | 0.71 | EGLN1 (1.00) | EGLN1 | |
| SCHEMBL620983 | 0.70 | EGLN1 (1.00) | EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006251-B2 | 4-aminoquinazolin-2-yl-1-pyrrazole-4-carboxylic acid compounds as prolyl hydroxylase inhibitors | JANSSEN PHARAMCEUTICA NV (BE) | 2015-04-14 | — | — | US | disclosed |