Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 15/20 | 0.77 |
| ▸ | TRIM58 | Q8NG06 | 2/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | PDE5A | O76074 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL621862 | 0.87 | EGLN1 (1.00) | EGLN1 | |
| SCHEMBL16638696 | 0.86 | EGLN1 (0.75) | EGLN1TRIM58HTR3AHRH4 | |
| SCHEMBL627593 | 0.83 | EGLN1 (0.69) | EGLN1TRIM58HTR3AHRH4PDE5A | |
| SCHEMBL10230034 | 0.74 | EGLN1 (1.00) | EGLN1 | |
| SCHEMBL628311 | 0.71 | EGLN1 (1.00) | EGLN1 | |
| SCHEMBL14992463 | 0.70 | EGLN1 (1.00) | EGLN1 | |
| SCHEMBL10229000 | 0.70 | EGLN1 (1.00) | EGLN1 | |
| SCHEMBL621250 | 0.69 | EGLN1 (1.00) | EGLN1 | |
| SCHEMBL3974310 | 0.68 | GBA1 (0.51) | EGLN1TRIM58HTR3AHRH4PDE5A | |
| SCHEMBL3644981 | 0.67 | KDM4E (0.69) | HTR3AHRH4PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006251-B2 | 4-aminoquinazolin-2-yl-1-pyrrazole-4-carboxylic acid compounds as prolyl hydroxylase inhibitors | JANSSEN PHARAMCEUTICA NV (BE) | 2015-04-14 | — | — | US | disclosed |