Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.52 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.47 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.47 |
| ▸ | ULK1 | O75385 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TERT | O14746 | 1/20 | 0.44 |
| ▸ | KHK | P50053 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3266041 | 0.86 | SCN3A (0.45) | SCN3ASCN9ASCN5AEPHX1EPHX2 | |
| SCHEMBL21580333 | 0.86 | SCN3A (0.52) | SCN3ASCN9ASCN5AEPHX2PSMB8 | |
| SCHEMBL10268098 | 0.84 | RXFP1 (0.53) | SCN3ASCN9ASCN5APSMB8ULK1 | |
| SCHEMBL17676974 | 0.84 | SCN3A (0.55) | SCN3ASCN9ASCN5AEPHX1PSMB8 | |
| SCHEMBL873241 | 0.84 | SCN3A (0.55) | SCN3ASCN9ASCN5AEPHX1PSMB8 | |
| SCHEMBL24609551 | 0.84 | SCN3A (0.55) | SCN3ASCN9ASCN5APSMB8ULK1 | |
| SCHEMBL10327297 | 0.84 | SCN3A (0.55) | SCN3ASCN9ASCN5AEPHX1PSMB8 | |
| SCHEMBL13388756 | 0.83 | SCN3A (0.64) | SCN3ASCN9ASCN5APSMB8RAB9A | |
| SCHEMBL2707503 | 0.82 | SCN3A (0.54) | SCN3ASCN9APSMB8ULK1 | |
| SCHEMBL29365790 | 0.82 | SCN3A (0.56) | SCN3ASCN9ASCN5AEPHX1PSMB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006454-B2 | Dihydroorotate dehydrogenase inhibitors | MERCK SERONO S.A. (CH) | 2015-04-14 | — | — | US | disclosed |