Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1303588 | 0.86 | APOBEC3G (0.46) | NOX4ALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL19956753 | 0.86 | NOX4 (0.38) | NOX4ALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL1302503 | 0.80 | NOX4 (0.40) | NOX4ALDH1A1MAPTKDM4EAPOBEC3G | |
| SCHEMBL1301676 | 0.72 | NOX4 (0.56) | NOX4 | |
| SCHEMBL2210536 | 0.72 | NOX4 (0.47) | NOX4APOBEC3GMAPK1 | |
| SCHEMBL19956775 | 0.72 | APOBEC3G (0.46) | ALDH1A1MAPTKDM4ESMN1; SMN2APOBEC3G | |
| SCHEMBL2219153 | 0.70 | NOX4 (0.45) | NOX4MAPTKDM4EAPOBEC3GTSHR | |
| SCHEMBL2217962 | 0.67 | NOX4 (0.43) | NOX4ALDH1A1MAPTRXFP1MAPK1 | |
| SCHEMBL2211500 | 0.66 | NOX4 (0.49) | NOX4ALDH1A1KDM4ETSHR | |
| SCHEMBL17171582 | 0.64 | NOX4 (0.48) | NOX4MAPTKDM4ERECQLUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2860179-A1 | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors | GenKyoTex SA (CH) | 2015-04-15 | — | — | EP | disclosed |