Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 17/20 | 0.61 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.61 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.61 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.61 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.61 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.61 |
| ▸ | PRKDC | P78527 | 2/20 | 0.61 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.61 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.61 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.61 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.61 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.61 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.61 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.57 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17053422 | 0.86 | PIK3CA (0.60) | MTORPIK3CAPIK3R1PIK3CDPIK3C2B | |
| SCHEMBL16639148 | 0.83 | PIK3CD (0.54) | MTORPIK3CAPIK3R1PIK3CDPIK3C2B | |
| SCHEMBL16639078 | 0.80 | PIK3CA (0.65) | MTORPIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL16639113 | 0.79 | PIK3CD (0.70) | PIK3CAPIK3CD | |
| SCHEMBL16639154 | 0.78 | PIK3CA (0.36) | MTORPIK3CAPIK3R1PIK3CDPIK3C2B | |
| SCHEMBL10327825 | 0.78 | MTOR (0.69) | MTORPIK3CAPIK3R1PIK3CDPIK3C2B | |
| SCHEMBL16639139 | 0.78 | PIK3CA (0.62) | MTORPIK3CAPIK3R1PIK3CDPIK3CG | |
| SCHEMBL760691 | 0.77 | MTOR (0.68) | MTORPIK3CAPIK3R1PIK3CDPIK3C2B | |
| SCHEMBL16639103 | 0.77 | PIK3CA (0.64) | MTORPIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL10327809 | 0.77 | PIK3CA (0.67) | MTORPIK3CAPIK3R1PIK3CDPIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9499561-B2 | Fused pyrimidine compound, and preparation method, intermediate, composition, and uses thereof | SHANGHAI YINGLI PHARMACEUTICAL CO., LTD. (CN) | 2016-11-22 | — | — | US | disclosed |
| US-20150246929-A1 | FUSED PYRIMIDINE COMPOUND, AND PREPARATION METHOD, INTERMEDIATE, COMPOSITION, AND USES THEREOF | SHANGHAI YUNYI HEALTHCARE AND TECHNOLOGY CO., LTD. (CN) | 2015-09-03 | — | — | US | disclosed |
| EP-2860181-A1 | FUSED PYRIMIDINE COMPOUND, AND PREPARATION METHOD, INTERMEDIATE, COMPOSITION AND USES THEREOF | Shanghai Yingli Science and Technology Co., Ltd (CN) | 2015-04-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246929-A1 | FUSED PYRIMIDINE COMPOUND, AND PREPARATION METHOD, INTERMEDIATE, COMPOSITION, AND USES THEREOF | PIK3CA, PIK3CD, PIK3CB | MTOR 51/4885PIK3CA 1/4885PIK3R1 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.