Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 17/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.68 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.68 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.68 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.68 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.68 |
| ▸ | PRKDC | P78527 | 2/20 | 0.68 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.68 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.68 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.68 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.68 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.68 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.68 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.63 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10327825 | 0.82 | MTOR (0.69) | MTORPIK3CAPIK3R1PIK3CDPIK3C2B | |
| SCHEMBL10327809 | 0.81 | PIK3CA (0.67) | MTORPIK3CAPIK3R1PIK3CDPIK3C2B | |
| Bimiralisib SCHEMBL1309049 | 0.81 | PIK3CA (1.00) | MTORPIK3CAPIK3R1PIK3CDPIK3C2B | |
| Bimiralisib SCHEMBL29352266 | 0.81 | PIK3CA (1.00) | MTORPIK3CAPIK3R1PIK3CDPIK3C2B | |
| Bimiralisib SCHEMBL29644978 | 0.80 | PIK3CA (0.98) | MTORPIK3CAPIK3R1PIK3CDPIK3C2B | |
| Bimiralisib SCHEMBL18428577 | 0.80 | PIK3CA (0.98) | MTORPIK3CAPIK3R1PIK3CDPIK3C2B | |
| SCHEMBL10328002 | 0.80 | PIK3CA (0.72) | MTORPIK3CAPIK3R1PIK3CDPIK3C2B | |
| Bimiralisib SCHEMBL17204454 | 0.79 | PIK3CA (0.95) | MTORPIK3CAPIK3R1PIK3CDPIK3C2B | |
| Bimiralisib SCHEMBL29644974 | 0.79 | PIK3CA (0.95) | MTORPIK3CAPIK3R1PIK3CDPIK3C2B | |
| SCHEMBL13016293 | 0.79 | PIK3R1 (0.83) | MTORPIK3CAPIK3R1PIK3CDPIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2261223-B1 | Pyrimidine derivatives used as pi-3 kinase inhibitors | NOVARTIS AG (CH) | 2013-06-12 | — | — | EP | claimed |
| EP-1984350-B1 | PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-08-18 | — | — | EP | claimed |
| EP-2429516-A2 | COMBINATION OF A PBOSPBOINOSITKLE 3-KS ASE INHIBITOR AND AN ANTIDIABETIC COMPOUND | Novartis AG (CH) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010130779-A2 | COMBINATION OF A PBOSPBOINOSITKLE 3-KSπASE INHIBITOR AND AN ANTIDIABETIC COMPOUND | NOVARTIS AG (CH) | 2010-11-18 | — | — | WO | disclosed |