Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 10/20 | 0.63 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.63 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.63 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.63 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1664913 | 0.88 | MAPT (0.59) | MAPK10MAPK8MAPK14MAPK13MAPK12 | |
| SCHEMBL13836623 | 0.88 | MAPK10 (0.56) | MAPK10MAPK8MAPK14MAPK13MAPK12 | |
| SCHEMBL13974467 | 0.87 | MAPK10 (0.58) | MAPK10MAPK8MAPK14MAPK13MAPK12 | |
| SCHEMBL8769687 | 0.87 | MAPT (0.54) | MAPK10MAPK8MAPK14MAPK13MAPK12 | |
| SCHEMBL1665410 | 0.87 | MAPT (0.52) | MAPK10MAPK8MAPK14MAPK13MAPK12 | |
| SCHEMBL13974299 | 0.84 | MAPT (0.49) | MAPK10MAPK8MAPK14MAPK13MAPK12 | |
| SCHEMBL1664427 | 0.84 | ALDH1A1 (0.52) | MAPK10MAPK8MAPK14MAPK13MAPK12 | |
| SCHEMBL1664065 | 0.84 | MAPT (0.54) | MAPK10MAPK8MAPK14MAPK13MAPK12 | |
| SCHEMBL8771404 | 0.84 | MAPT (0.67) | MAPK10MAPK8MAPK14MAPK13MAPK12 | |
| SCHEMBL1664312 | 0.83 | MAPK10 (0.59) | MAPK10MAPK8MAPK14MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |