Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 3/20 | 0.49 |
| ▸ | ITGAM | P11215 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 9/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.41 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.40 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 7/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | POLB | P06746 | 5/20 | 0.39 |
| ▸ | RECQL | P46063 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17789558 | 0.90 | ITGB2 (0.59) | ITGB2ITGAMMAPTTP53PSMB8 | |
| SCHEMBL16639742 | 0.82 | ITGB2 (0.53) | ITGB2ITGAMMAPTNR1H4PTGES | |
| SCHEMBL23692386 | 0.77 | EP300 (0.44) | ITGB2ITGAMMAPTDUSP3PTPN7 | |
| SCHEMBL15315392 | 0.76 | POLB (0.50) | ITGB2ITGAMMAPTPSMB8DUSP3 | |
| SCHEMBL684060 | 0.75 | ITGB2 (0.80) | ITGB2ITGAMPSMB8MEN1KMT2A | |
| SCHEMBL16639747 | 0.75 | MEN1 (0.44) | MAPTDUSP3PTPN7MEN1KMT2A | |
| SCHEMBL16639743 | 0.73 | DUSP3 (0.56) | MAPTPSMB8DUSP3PTPN7PTGES | |
| SCHEMBL16639751 | 0.72 | ITGB2 (0.62) | ITGB2ITGAMMAPTNR1H4MEN1 | |
| SCHEMBL16687570 | 0.71 | KDM4E (0.58) | MAPTPSMB8DUSP3PTPN7MEN1 | |
| SCHEMBL15374273 | 0.70 | HIF1AN (0.56) | MAPTDUSP3PTPN7MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9328105-B2 | Compounds and methods for regulating integrins | ADHAERE PHARMACEUTICALS, INC. (US) | 2016-05-03 | — | — | US | disclosed |
| US-20150105435-A1 | COMPOUNDS AND METHODS FOR REGULATING INTEGRINS | ATEGRIN, INC. | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105435-A1 | COMPOUNDS AND METHODS FOR REGULATING INTEGRINS | ITGA2, ITGB2, ITGA2B | ITGB2 2/4885ITGAM 9/4885MAPT 4654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.