Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROR1 | Q01973 | 13/20 | 0.94 |
| ▸ | CSF1R | P07333 | 1/20 | 0.65 |
| ▸ | ABL1 | P00519 | 6/20 | 0.65 |
| ▸ | ABL2 | P42684 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30987917 | 0.97 | ROR1 (1.00) | ROR1CSF1RABL1 | |
| SCHEMBL30987894 | 0.86 | ROR1 (0.81) | ROR1CSF1RABL1ABL2 | |
| SCHEMBL30987915 | 0.84 | ROR1 (0.75) | ROR1CSF1RABL1ABL2 | |
| SCHEMBL19317721 | 0.82 | ROR1 (0.79) | ROR1CSF1RABL1 | |
| SCHEMBL16644466 | 0.82 | CSF1R (0.75) | ROR1CSF1RABL1 | |
| SCHEMBL16250614 | 0.81 | ABL1 (0.80) | ROR1CSF1RABL1ABL2 | |
| SCHEMBL30987922 | 0.80 | ROR1 (0.69) | ROR1CSF1RABL1ABL2 | |
| SCHEMBL12682241 | 0.80 | ROR1 (0.72) | ROR1CSF1RABL1ABL2 | |
| SCHEMBL30987865 | 0.80 | ROR1 (0.86) | ROR1CSF1RABL1 | |
| SCHEMBL16644461 | 0.80 | ABL1 (0.84) | ROR1CSF1RABL1ABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150105377-A1 | Methods and Compositions for RAF Kinase Mediated Diseases | ARIAD PHARMACEUTICALS, INC. | 2015-04-16 | — | — | US | disclosed |
| US-20150105377-A1 | Methods and Compositions for RAF Kinase Mediated Diseases | ARIAD PHARMACEUTICALS, INC. | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105377-A1 | Methods and Compositions for RAF Kinase Mediated Diseases | BRAF, RAF1, NRAS | ROR1 263/4885CSF1R 2599/4885ABL1 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.