Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 7/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1664091 | 0.96 | HPGDS (0.50) | HPGDSSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1664250 | 0.91 | HPGDS (0.46) | HPGDSSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1664071 | 0.90 | HPGDS (0.45) | HPGDSSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL8770806 | 0.90 | HPGDS (0.50) | HPGDSSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1665847 | 0.89 | HPGDS (0.53) | HPGDSSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1665001 | 0.89 | HPGDS (0.44) | HPGDSSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1664977 | 0.89 | HPGDS (0.44) | HPGDSSMN1; SMN2RAB9AMAPTALDH1A1 | |
| SCHEMBL1664854 | 0.88 | HPGDS (0.50) | HPGDSSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1664890 | 0.88 | HPGDS (0.43) | HPGDSSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1664254 | 0.86 | HPGDS (0.44) | HPGDSSMN1; SMN2NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |