Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.57 |
| ▸ | NPC1 | O15118 | 7/20 | 0.57 |
| ▸ | PKM | P14618 | 7/20 | 0.57 |
| ▸ | MAPT | P10636 | 8/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1664334 | 0.96 | NPC1 (0.53) | RAB9ANPC1PKMMAPTSMN1; SMN2 | |
| SCHEMBL1664249 | 0.78 | NPC1 (0.46) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1664638 | 0.78 | EGFR (0.44) | RAB9ANPC1PKMMAPTSMN1; SMN2 | |
| SCHEMBL21254567 | 0.78 | RAB9A (0.71) | RAB9ANPC1PKMMAPTSMN1; SMN2 | |
| SCHEMBL1664033 | 0.78 | MAPT (0.46) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1664754 | 0.77 | NPC1 (0.46) | RAB9ANPC1PKMMAPTSMN1; SMN2 | |
| SCHEMBL1667494 | 0.77 | PDE7A (0.46) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8769706 | 0.76 | RAB9A (0.58) | RAB9ANPC1PKMMAPTSMN1; SMN2 | |
| SCHEMBL1664252 | 0.75 | MAPT (0.50) | RAB9ANPC1PKMMAPTSMN1; SMN2 | |
| SCHEMBL1664639 | 0.75 | RAB9A (0.50) | RAB9ANPC1PKMMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |