Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 20/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL170973 | 0.83 | NAMPT (0.75) | NAMPTCYP2C9 | |
| SCHEMBL12468034 | 0.82 | NAMPT (0.74) | NAMPTCYP2C9 | |
| SCHEMBL173312 | 0.81 | NAMPT (0.78) | NAMPTCYP2C9 | |
| SCHEMBL170901 | 0.80 | NAMPT (0.77) | NAMPTCYP2C9HDAC3HDAC1HDAC2 | |
| SCHEMBL174840 | 0.80 | NAMPT (0.80) | NAMPTCYP2C9HDAC1 | |
| SCHEMBL168504 | 0.80 | NAMPT (0.83) | NAMPTCYP2C9 | |
| SCHEMBL160762 | 0.78 | NAMPT (0.80) | NAMPTCYP2C9 | |
| SCHEMBL12468236 | 0.78 | NAMPT (0.84) | NAMPTCYP2C9 | |
| SCHEMBL173943 | 0.78 | NAMPT (0.94) | NAMPTCYP2C9 | |
| SCHEMBL24859169 | 0.77 | NAMPT (0.67) | NAMPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150104384-A1 | AMIDO-BENZYL SULFONE AND SULFOXIDE DERIVATIVES | VALO HEALTH, INC. | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150104384-A1 | AMIDO-BENZYL SULFONE AND SULFOXIDE DERIVATIVES | STS, SULT1E1, CBS | NAMPT 759/4885CYP2C9 211/4885HDAC3 425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.