CBS

Cystathionine beta-synthase · P35520 · CBS on Sugi Atlas →

3,056 patent compounds predicted against CBS, 2,561 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Cupressuflavone (SCHEMBL505213)	1.00	2/20
Agathisflavone (SCHEMBL616142)	1.00	2/20
Cupressuflavone (SCHEMBL4650575)	0.97	2/20
SCHEMBL476215	0.78	2/20
Morelloflavone (SCHEMBL615093)	0.73	2/20
Morelloflavone (SCHEMBL2383075)	0.73	2/20
SCHEMBL617814	0.71	2/20
Sequoiaflavone (SCHEMBL1158361)	0.62	2/20
Ginkgetin (SCHEMBL888410)	0.60	2/20
SCHEMBL6614337	0.56	2/20
SCHEMBL1067942	0.56	2/20
SCHEMBL4742819	0.55	2/20
SCHEMBL312444	0.54	2/20
SCHEMBL222227	0.53	2/20
SCHEMBL706527	0.50	2/20
SCHEMBL6360019	0.50	2/20
SCHEMBL6363033	0.50	2/20
SCHEMBL1066027	0.49	2/20
Aurintricarboxylic Acid (SCHEMBL98495)	1.00	1/20
SCHEMBL3486974	1.00	1/20

Clinical trials — most relevant to CBS by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis	PHASE4	COMPLETED
Study With Heptral in Subjects With Liver Disease Due to Alcohol Consumption	PHASE3	COMPLETED
Betaine METABOLISM OF PATIENTS With Homocystinuria	PHASE2	COMPLETED
Oxidative Stress Markers In Inherited Homocystinuria And The Impact Of Taurine	PHASE1/PHASE2	COMPLETED
Homocystinuria: Treatment With N-Acetylcysteine	PHASE2	COMPLETED
Methimazole in Patients With Progressive Glioblastoma	PHASE2	RECRUITING
Pegtibatinase As an Enzyme Therapy for Patients with Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency (COMPOSE)	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
Evaluation of Thiosulfate in End Stage Renal Disease and Kidney Transplantation	PHASE1	COMPLETED
The Effect of Dietary Management and Cysteine Supplementation on Growth Parameters and Biochemical Control for Pediatric Qatari Patients Affected with Classical B6 Non-responsive Homocystinuria.	nan	NOT_YET_RECRUITING
Proof of Concept Creatine Supplementation for Homocystinuria Study	nan	ACTIVE_NOT_RECRUITING
Hydrogen Sulfide as Prognostic Factor	nan	COMPLETED
Dietary Effects of Sulfur Amino Acids	nan	COMPLETED
Effects of Exercise on Metabolic Parameters in Classical Homocystinuria	nan	COMPLETED
Study of Homocysteine Metabolism in Homocystinuria	nan	COMPLETED
Natural History Study of Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency (ACAPPELLA)	nan	RECRUITING
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione	nan	COMPLETED
Incidence and Risk Factors of Ocular Complications Among Patients With Homocystinuria	nan	ENROLLING_BY_INVITATION
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients.	nan	COMPLETED
External Nitric Oxide Measurement Through SNO Degradation	nan	ENROLLING_BY_INVITATION
Early Nutritional Intervention in Patients With Autism Spectrum Disorders	nan	COMPLETED
Evaluation of Mitochondrial Enzyme Activity in Cesarean Section Patients	nan	UNKNOWN
Methionine and Cysteine Restriction in Humans	nan	COMPLETED
Homocysteine and Coronary Artery Disease	nan	COMPLETED
Treating Oxidative Stress and the Metabolic Pathology of Autism	nan	COMPLETED
Effect of Adding Folic Acid on Lipid Parameters in Population With Dyslipidemias	nan	UNKNOWN
Effects of Homocysteine in Myocardial Infarction Patients in a Tertiary Care Hospital of Pakistan	nan	WITHDRAWN
Health Related Quality of Life (HrQoL) in Classical Homocystinuria (CBS Deficiency)	nan	RECRUITING
Vitamin B-6 and Glutathione on Inflammation, Homocysteine, Oxidative Stress and Antioxidant Capacities	nan	UNKNOWN
Thiol/Disulphide Homeostasis in Unexplained Infertility	nan	COMPLETED
Efficacy of Essential Phospholipid Versus Betaine HCL/L-Glutamic Acid in MAFLD	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a CBS binder may also engage these)

Protein	Name	Similarity
Q58H57	—	1.000	Q58H57 →
Q9N0V7	—	1.000	Q9N0V7 →
P32232	—	1.000	P32232 →
Q91WT9	—	0.996	Q91WT9 →
P46794	—	0.996	P46794 →
P13228	—	0.986	P13228 →
A8NEP3	—	0.986	A8NEP3 →
P00927	—	0.986	P00927 →
Q1KLZ1	—	0.986	Q1KLZ1 →
Q2V0C9	—	0.985	Q2V0C9 →
Q9NWZ5	—	0.985	Q9NWZ5 →
P43284	—	0.984	P43284 →
A9BD24	—	0.983	A9BD24 →
Q9AXU4	—	0.983	Q9AXU4 →
P00931	—	0.982	P00931 →
Q9ZSS6	—	0.982	Q9ZSS6 →
P50867	—	0.982	P50867 →
P32260	—	0.982	P32260 →
Q8AWD2	—	0.982	Q8AWD2 →
Q8TB37	—	0.982	Q8TB37 →
P25269	—	0.982	P25269 →
O50046	—	0.982	O50046 →
Q5E623	—	0.981	Q5E623 →
B5FDB7	—	0.981	B5FDB7 →
Q57AF0	—	0.981	Q57AF0 →
Q2YQW5	—	0.981	Q2YQW5 →
B2S9A5	—	0.981	B2S9A5 →
Q9R060	—	0.981	Q9R060 →
A9KTR7	—	0.981	A9KTR7 →
Q6LPA4	—	0.981	Q6LPA4 →